For me, the classic road-trip music will always be Roadrunner by Jonathan Richman and the Modern Lovers (the original lineup included Jerry Harrison, who was a founding member of Talking Heads, and David Robinson, who drummed for The Cars). Here's a live version that, I confess, I'd never heard before:
Of course, Roadrunner sounds suspiciously like Sister Ray, by the Velvet Underground:
Roadrunner has become somewhat of a standard. Joan Jett tackled it:
The song was also hilariously butchered by the Sex Pistols in a rehearsal, with a confused John Lydon ad-libbing in quite entertaining fashion:
Mojo Nixon & Skid Roper's Jesus at McDonald's was a tongue-in-cheek "tribute" to the song:
The song's got legs, which is pretty outstanding for a love song to Stop and Shop.